A monocentric study of steroid-refractory acute graft-versus-host disease treatment with tacrolimus and mTOR inhibitor.
Identifieur interne : 000157 ( Main/Exploration ); précédent : 000156; suivant : 000158A monocentric study of steroid-refractory acute graft-versus-host disease treatment with tacrolimus and mTOR inhibitor.
Auteurs : Alienor Xhaard [France] ; Manon Launay [France] ; Flore Sicre De Fontbrune [France] ; David Michonneau [France] ; Aurelien Sutra Del Galy [France] ; Tereza Coman [France] ; Simona Pagliuca [France] ; Nathalie Dhedin [France] ; Marie Robin [France] ; Regis Peffault De Latour [France] ; Gerard Socie [France]Source :
- Bone marrow transplantation [ 1476-5365 ] ; 2020.
Abstract
Acute graft-versus-host disease (aGVHD) remains one of the leading causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. No consensus exists on the best second-line treatment of steroid-refractory acute GVHD (SR-aGVHD). Previously published smaller studies on the use of sirolimus in SR-aGVHD treatment report a response rate of 57 to 86%, with 40% overall survival. The association of tacrolimus and mTOR inhibitor is supported by pre-clinical data and has been used as GVHD prophylaxis. We report 42 patients who received tacrolimus and mTOR inhibitor as a second- or third-line treatment of SR-aGVHD. Thirty-one patients were treated in second-line, with an overall response rate of 48.5% (complete response: 42%). Eleven patients were treated in third-line, with an overall response rate of 27%. Thirty-eight patients had at least one episode of infection, due to bacteria, viruses, fungi and parasites in 61, 42, 12 and two episodes, respectively. For patients treated in second-line, six-month and one-year survival were 61% and 42%, respectively. None of the patients treated in third-line survived. These results were not promising enough to initiate a phase three randomized clinical trial, but tacrolimus and mTOR inhibitor can be discussed among other options for patients with SR-aGVHD.
DOI: 10.1038/s41409-019-0633-y
PubMed: 31413313
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A monocentric study of steroid-refractory acute graft-versus-host disease treatment with tacrolimus and mTOR inhibitor.</title><author><name sortKey="Xhaard, Alienor" sort="Xhaard, Alienor" uniqKey="Xhaard A" first="Alienor" last="Xhaard">Alienor Xhaard</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France. alienor.xhaard@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Launay, Manon" sort="Launay, Manon" uniqKey="Launay M" first="Manon" last="Launay">Manon Launay</name><affiliation wicri:level="3"><nlm:affiliation>Service de pharmacologie, Hôpital Européen Georges-Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de pharmacologie, Hôpital Européen Georges-Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sicre De Fontbrune, Flore" sort="Sicre De Fontbrune, Flore" uniqKey="Sicre De Fontbrune F" first="Flore" last="Sicre De Fontbrune">Flore Sicre De Fontbrune</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Michonneau, David" sort="Michonneau, David" uniqKey="Michonneau D" first="David" last="Michonneau">David Michonneau</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sutra Del Galy, Aurelien" sort="Sutra Del Galy, Aurelien" uniqKey="Sutra Del Galy A" first="Aurelien" last="Sutra Del Galy">Aurelien Sutra Del Galy</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Coman, Tereza" sort="Coman, Tereza" uniqKey="Coman T" first="Tereza" last="Coman">Tereza Coman</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pagliuca, Simona" sort="Pagliuca, Simona" uniqKey="Pagliuca S" first="Simona" last="Pagliuca">Simona Pagliuca</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dhedin, Nathalie" sort="Dhedin, Nathalie" uniqKey="Dhedin N" first="Nathalie" last="Dhedin">Nathalie Dhedin</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie adolescents-jeunes adultes, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie adolescents-jeunes adultes, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Robin, Marie" sort="Robin, Marie" uniqKey="Robin M" first="Marie" last="Robin">Marie Robin</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Peffault De Latour, Regis" sort="Peffault De Latour, Regis" uniqKey="Peffault De Latour R" first="Regis" last="Peffault De Latour">Regis Peffault De Latour</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR1160, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR1160, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31413313</idno><idno type="pmid">31413313</idno><idno type="doi">10.1038/s41409-019-0633-y</idno><idno type="wicri:Area/Main/Corpus">000208</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000208</idno><idno type="wicri:Area/Main/Curation">000208</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000208</idno><idno type="wicri:Area/Main/Exploration">000208</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A monocentric study of steroid-refractory acute graft-versus-host disease treatment with tacrolimus and mTOR inhibitor.</title><author><name sortKey="Xhaard, Alienor" sort="Xhaard, Alienor" uniqKey="Xhaard A" first="Alienor" last="Xhaard">Alienor Xhaard</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France. alienor.xhaard@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Launay, Manon" sort="Launay, Manon" uniqKey="Launay M" first="Manon" last="Launay">Manon Launay</name><affiliation wicri:level="3"><nlm:affiliation>Service de pharmacologie, Hôpital Européen Georges-Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de pharmacologie, Hôpital Européen Georges-Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sicre De Fontbrune, Flore" sort="Sicre De Fontbrune, Flore" uniqKey="Sicre De Fontbrune F" first="Flore" last="Sicre De Fontbrune">Flore Sicre De Fontbrune</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Michonneau, David" sort="Michonneau, David" uniqKey="Michonneau D" first="David" last="Michonneau">David Michonneau</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sutra Del Galy, Aurelien" sort="Sutra Del Galy, Aurelien" uniqKey="Sutra Del Galy A" first="Aurelien" last="Sutra Del Galy">Aurelien Sutra Del Galy</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Coman, Tereza" sort="Coman, Tereza" uniqKey="Coman T" first="Tereza" last="Coman">Tereza Coman</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pagliuca, Simona" sort="Pagliuca, Simona" uniqKey="Pagliuca S" first="Simona" last="Pagliuca">Simona Pagliuca</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dhedin, Nathalie" sort="Dhedin, Nathalie" uniqKey="Dhedin N" first="Nathalie" last="Dhedin">Nathalie Dhedin</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie adolescents-jeunes adultes, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie adolescents-jeunes adultes, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Robin, Marie" sort="Robin, Marie" uniqKey="Robin M" first="Marie" last="Robin">Marie Robin</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Peffault De Latour, Regis" sort="Peffault De Latour, Regis" uniqKey="Peffault De Latour R" first="Regis" last="Peffault De Latour">Regis Peffault De Latour</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR1160, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR1160, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Bone marrow transplantation</title><idno type="eISSN">1476-5365</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute graft-versus-host disease (aGVHD) remains one of the leading causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. No consensus exists on the best second-line treatment of steroid-refractory acute GVHD (SR-aGVHD). Previously published smaller studies on the use of sirolimus in SR-aGVHD treatment report a response rate of 57 to 86%, with 40% overall survival. The association of tacrolimus and mTOR inhibitor is supported by pre-clinical data and has been used as GVHD prophylaxis. We report 42 patients who received tacrolimus and mTOR inhibitor as a second- or third-line treatment of SR-aGVHD. Thirty-one patients were treated in second-line, with an overall response rate of 48.5% (complete response: 42%). Eleven patients were treated in third-line, with an overall response rate of 27%. Thirty-eight patients had at least one episode of infection, due to bacteria, viruses, fungi and parasites in 61, 42, 12 and two episodes, respectively. For patients treated in second-line, six-month and one-year survival were 61% and 42%, respectively. None of the patients treated in third-line survived. These results were not promising enough to initiate a phase three randomized clinical trial, but tacrolimus and mTOR inhibitor can be discussed among other options for patients with SR-aGVHD.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31413313</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5365</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>01</Month></PubDate></JournalIssue><Title>Bone marrow transplantation</Title><ISOAbbreviation>Bone Marrow Transplant</ISOAbbreviation></Journal><ArticleTitle>A monocentric study of steroid-refractory acute graft-versus-host disease treatment with tacrolimus and mTOR inhibitor.</ArticleTitle><Pagination><MedlinePgn>86-92</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41409-019-0633-y</ELocationID><Abstract><AbstractText>Acute graft-versus-host disease (aGVHD) remains one of the leading causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. No consensus exists on the best second-line treatment of steroid-refractory acute GVHD (SR-aGVHD). Previously published smaller studies on the use of sirolimus in SR-aGVHD treatment report a response rate of 57 to 86%, with 40% overall survival. The association of tacrolimus and mTOR inhibitor is supported by pre-clinical data and has been used as GVHD prophylaxis. We report 42 patients who received tacrolimus and mTOR inhibitor as a second- or third-line treatment of SR-aGVHD. Thirty-one patients were treated in second-line, with an overall response rate of 48.5% (complete response: 42%). Eleven patients were treated in third-line, with an overall response rate of 27%. Thirty-eight patients had at least one episode of infection, due to bacteria, viruses, fungi and parasites in 61, 42, 12 and two episodes, respectively. For patients treated in second-line, six-month and one-year survival were 61% and 42%, respectively. None of the patients treated in third-line survived. These results were not promising enough to initiate a phase three randomized clinical trial, but tacrolimus and mTOR inhibitor can be discussed among other options for patients with SR-aGVHD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xhaard</LastName><ForeName>Alienor</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4449-989X</Identifier><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France. alienor.xhaard@aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Launay</LastName><ForeName>Manon</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service de pharmacologie, Hôpital Européen Georges-Pompidou, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sicre de Fontbrune</LastName><ForeName>Flore</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michonneau</LastName><ForeName>David</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4553-3065</Identifier><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sutra Del Galy</LastName><ForeName>Aurelien</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4716-1472</Identifier><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coman</LastName><ForeName>Tereza</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pagliuca</LastName><ForeName>Simona</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dhedin</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Service d'hématologie adolescents-jeunes adultes, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robin</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peffault de Latour</LastName><ForeName>Regis</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Socie</LastName><ForeName>Gerard</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2114-7533</Identifier><AffiliationInfo><Affiliation>Service d'hématologie-greffe, Hôpital Saint-Louis, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm UMR1160, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>08</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Bone Marrow Transplant</MedlineTA><NlmUniqueID>8702459</NlmUniqueID><ISSNLinking>0268-3369</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>06</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>06</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31413313</ArticleId><ArticleId IdType="doi">10.1038/s41409-019-0633-y</ArticleId><ArticleId IdType="pii">10.1038/s41409-019-0633-y</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Xhaard, Alienor" sort="Xhaard, Alienor" uniqKey="Xhaard A" first="Alienor" last="Xhaard">Alienor Xhaard</name></region><name sortKey="Coman, Tereza" sort="Coman, Tereza" uniqKey="Coman T" first="Tereza" last="Coman">Tereza Coman</name><name sortKey="Dhedin, Nathalie" sort="Dhedin, Nathalie" uniqKey="Dhedin N" first="Nathalie" last="Dhedin">Nathalie Dhedin</name><name sortKey="Launay, Manon" sort="Launay, Manon" uniqKey="Launay M" first="Manon" last="Launay">Manon Launay</name><name sortKey="Michonneau, David" sort="Michonneau, David" uniqKey="Michonneau D" first="David" last="Michonneau">David Michonneau</name><name sortKey="Pagliuca, Simona" sort="Pagliuca, Simona" uniqKey="Pagliuca S" first="Simona" last="Pagliuca">Simona Pagliuca</name><name sortKey="Peffault De Latour, Regis" sort="Peffault De Latour, Regis" uniqKey="Peffault De Latour R" first="Regis" last="Peffault De Latour">Regis Peffault De Latour</name><name sortKey="Robin, Marie" sort="Robin, Marie" uniqKey="Robin M" first="Marie" last="Robin">Marie Robin</name><name sortKey="Sicre De Fontbrune, Flore" sort="Sicre De Fontbrune, Flore" uniqKey="Sicre De Fontbrune F" first="Flore" last="Sicre De Fontbrune">Flore Sicre De Fontbrune</name><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name><name sortKey="Sutra Del Galy, Aurelien" sort="Sutra Del Galy, Aurelien" uniqKey="Sutra Del Galy A" first="Aurelien" last="Sutra Del Galy">Aurelien Sutra Del Galy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000157 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000157 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31413313
|texte= A monocentric study of steroid-refractory acute graft-versus-host disease treatment with tacrolimus and mTOR inhibitor.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31413313" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |